生态室研究员简介

宋万通  博士

研究员  博士生导师  高分子化学专业

生物高分子研究组

办公室：合成楼517房间

电　话：+86-431-85262518

传　真：+86-431-85262518

教育和工作经历

2004-2008，南京大学，应用化学专业，理学学士

2008-2013，中国科学院大学，高分子化学专业，理学博士

2013-2015，中国科学院长春应用化学研究所，助理研究员

2015-2021，中国科学院长春应用化学研究所，副研究员

2016-2018，美国北卡罗来纳大学教堂山分校，博士后

2021-现在，中国科学院长春应用化学研究所，研究员

研究领域和现状

主要研究方向为生物医用高分子材料，包括肿瘤疫苗、药物/基因递送载体、局部缓释药物载体、肿瘤免疫治疗等。

作为项目负责人先后承担国家自然科学基金委、中科院、吉林省科技厅、长春市科技局等项目10余项；先后在Nature Nanotechnology、Nature Communications、Advanced Materials等杂志发表论文70余篇，申请中国发明专利20余项。曾获得2018年度美中抗癌协会和亚洲癌症研究基金会青年学者奖，2019年度中美纳米医学与纳米生物技术学会未来之星奖；目前担任中国生物医学工程学会纳米医学与工程分会青年委员，并于2019年入选中国科学院青年创新促进会。

主要代表性论文

1. Jiayu Zhao, Yudi Xu, Sheng Ma, Yibo Wang, Zichao Huang, Haoyuan Qu, Haochen Yao, Yu Zhang, Guanglu Wu, Leaf Huang, Wantong Song*, Zhaohui Tang, Xuesi Chen, A Minimalist Binary Vaccine Carrier for Personalized Postoperative Cancer Vaccine Therapy, Adv Mater. 2022, 34(3): 2109254.

2. Yu Zhang, Sheng Ma, Xinming Liu, Yudi Xu, Jiayu Zhao, Xinghui Si, Hongxiang Li, Zichao Huang, Zhenxin Wang, Zhaohui Tang, Wantong Song*, Xuesi Chen*, Supramolecular Assembled Programmable Nanomedicine As In Situ Cancer Vaccine for Cancer Immunotherapy, Adv Mater.. 2021, 33(7): 2007293.

3. Guofeng Ji, Yu Zhang, Xinghui Si, Haochen Yao, Sheng Ma, Yudi Xu, Jiayu Zhao, Chong Ma, Chaoliang He, Zhaohui Tang, Xuedong Fang*, Wantong Song*, Xuesi Chen, Biopolymer Immune Implants' Sequential Activation of Innate and Adaptive Immunity for Colorectal Cancer Postoperative Immunotherapy, Adv Mater.. 2021, 33(3): 2004559.

4. Guofeng Ji, Xinghui Si, Si Dong, Yajun Xu, Mingqiang Li, Bo Yang, Zhaohui Tang, Xuedong Fang, Leaf Huang*, Wantong Song*, Xuesi Chen, Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy, Nano Lett. 2021, 21(16): 6781-6791.

5. Sheng Ma, Wantong Song*, Yudi Xu, Xinghui Si, Shixian Lv, Yu Zhang, Zhaohui Tang, Xuesi Chen*, Rationally Designed Polymer Conjugate for Tumor-Specific Amplification of Oxidative Stress and Boosting Antitumor Immunity, NANO LETT. 2020, 20(4): 2514-2521.

6. Wantong Song*, Manisit Das, Xuesi Chen, Nanotherapeutics for Immuno-Oncology: A Crossroad for New Paradigms, Trends Cancer. 2020, 6(4): 288-298.

7. Wantong Song, Aaron C. Anselmo*, Leaf Huang*, Nanotechnology Intervention of the Microbiome for Cancer Therapy, Nat Nanotechnol. 2019, 14(12): 1093-1103.

8. Wantong Song, Karthik Tiruthani, Ying Wang, Limei Shen, Mengying Hu, Oleksandra Dorosheva, Kunyu Qiu, Karina A. Kinghorn, Rihe Liu*, Leaf Huang*, Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis, Adv Mater. 2018, 30(52): 1805007.

9. Wantong Song, Limei Shen, Ying Wang, Qi Liu, Tyler J. Goodwin, Jingjing Li, Olekasandra Dorosheva, Tianzhou Liu, Rihe Liu*, Leaf Huang*, Synergistic and Low Adverse Effect Cancer Immunotherapy by Immunogenic Chemotherapy and Locally Expressed PD-L1 Trap, Nat Commun. 2018, 9: 2237.

10. Wantong Song, Sara N. Musetti, Leaf Huang*, Nanomaterials for Cancer Immunotherapy, Biomaterials. 2017, 148: 16-30.