生态室研究员简介

汤朝晖 博士

研究员   博士生导师   高分子化学专业

国家杰出青年科学基金获得者（2020）

生物高分子研究组

办公室：合成楼121房间

电　话：+86-431-85262449

传　真：+86-431-85682116

E-mail： ztang@ciac.ac.cn

教育和工作经历

1995-1999，湘潭大学，应用化学专业，本科

1999-2004，中科院长春应用化学研究所，高分子化学与物理专业，博士

2005-2006，英国帝国理工学院（Imperial College London），博士后

2007-2008，美国纽约州立大学石溪分校（SUNY at Stone Brook），博士后

2009-2014，中科院长春应用化学研究所，副研究员

2015-现在，中科院长春应用化学研究所，研究员 

研究资助

国家自然科学基金面上项目、国家科技重大专项重大新药创制项目、吉林省科技发展计划重点项目、吉林省医药产业发展专项资金项目

获奖及荣誉

1. 2011年入选中科院青年创新促进会

2. 2015年入选中科院青年创新促进会“优秀会员”

3. 2020年获得国家杰出青年科学基金资助

研究领域

生物可降解高分子药物载体；纳米药物；肿瘤靶向药物递送；癌症治疗宿主免疫反应；免疫治疗

主要代表性论文

1. Wang,Y.; Shen, N.; Wang, Y.;Zhang, Y.;Tang, Z.;Chen, X.,Self-amplifying Nanotherapeutic Drugs Homing to Tumors in a Manner of Chain Reaction.Adv. Mater. In press.

2. Zhao, J.;Ma, S.; Xu, Y.; Si, X.; Yao, H.;Huang, Z.;Zhang, Y.;Yu, H.;Tang, Z.; Song, W.;Chen, X., In situ activation of STING pathway with polymeric SN38 for cancer chemoimmunotherapy, Biomaterials 268 (2021) 120542.

3. Si, X.;Ma, S.;Xu, Y.;Zhang, D.;Shen, N.;Yu, H.; Zhang, Y.; Song, W.;Tang, Z.; Chen,X., Hypoxia-sensitive supramolecular nanogels for the cytosolic delivery of ribonuclease A as a breast cancer therapeutic, J. Control. Release2020,320, 83-95.

4. Liu, Z. Yu, H.; Shen, N.;Tang, Z.;Chen, X.,A ROS-Stimulus-Responsive Nanocarrier Loading with Guanidine-Modified Hydroxycamptothecin Prodrug for Enhanced Anti-Tumor Efficacy, CCS Chemistry 2020, 305-316.

5. Shen, N.; Wu, J.; Yang, C.; Yu, H.;Yang, S.;Li, T.;Chen, J.;Tang, Z.; Chen, X., Combretastatin A4 Nanoparticles Combined with Hypoxia-Sensitive Imiquimod: A New Paradigm for the Modulation of Host Immunological Responses during Cancer Treatment, Nano Lett.2019,19(11),8021-8031.

6. Yang, S.; Tang, Z.; Hu, C.; Zhang, D.; Shen, N.; Yu, H.; Chen, X., SelectivelyPotentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia-Activated Prodrug Tirapazamine Therapy forMetastatic Tumors. Adv. Mater. 2019, 31, 1805955. (IF=25.809)

7. Qin, H.; Yu, H.; Sheng, J.; Zhang, D.; Shen, N.; Liu, L.; Tang, Z.; Chen, X.,PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l-GlutamicAcid)-Combretastatin A4 Conjugate in Metastatic Breast Cancer. Adv. Sci. 2019,6, 1900327. (IF=15.804)

8. Wang, Y.; Yu, H.; Zhang, D.; Wang, G.; Song, W.; Liu, Y.; Ma, S.; Tang, Z.; Liu,Z.; Sakurai, K.; Chen, X.,Co-administrationof Combretastatin A4 NanoparticlesandSorafenibfor Systemic TherapyofHepatocellular Carcinoma. ActaBiomater. 2019, 92, 229-240.(IF=6.638)

9. Zhou, H.; Lv, S.; Zhang, D.; Deng, M.; Zhang, X.; Tang, Z.; Chen, X., APolypeptide Based Podophyllotoxin Conjugate for the Treatment of Multi DrugResistant Breast Cancer with Enhanced Efficiency and Minimal Toxicity. ActaBiomater.. 2018, 73, 388-399. (IF=6.638)

10. Ly, S.; Tang, Z.; Song, W.; Zhang, D.; Li, M.; Liu, H.; Cheng, J.; Zhong, W.; Chen, X., Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-PenetratingNanomedicine. Small 2017,13, 1600954. (IF=10.856)

11.Tang, Z.; He, C.; Tian, H.; Ding, J.; Hsiao, B. S.; Chu, B.; Chen, X., PolymericNanostructured Materials for Biomedical Applications. Prog. Polym. Sci. 2016,60, 86-128. (IF=24.505)

12. Song, W.; Tang, Z.; Zhang, D.; Wen, X.; Lv, S.; Liu, Z.; Deng, M.; Chen, X.,Solid Tumor Therapy Using a Cannon and Pawn Combination Strategy.Theranostics 2016, 6, 1023-1030. (IF= 8.063)

13. Song, W.; Tang, Z.; Zhang, D.; Li, M.; Gu, J.; Chen, x., A Cooperative Polymeric Platform for Tumor-targeted Drug Delivery. Chem. Sci. 2016, 7, 728-736. (IF=9.556)

14. Song, W.; Tang, Z.; Shen, N; Yu, H.; Jia, Y.; Zhang, D.; Jiang, J.; He, C.; Tian, H.; Chen, X.， Combining Disulfiram and Poly(l-glutamic acid)-cisplatinconjugates for Combating Cisplatin Resistance. J. Controlled Release 2016, 231,94-102. (IF=7.901)

15. Yu, H.; Tang, Z.; Zhang, D.; Song, W.; Zhang, Y.; Yang, Y.; Ahmad, Z.; Chen,X., Pharmacokinetics, Biodistribution and in Vivo Efficacy of Cisplatin Loadedfor Tumor Therapy. J. Controlled Release 2015, 205, 89-97. (IF=7.901)

16. Song, W.; Tang, Z.; Zhang, D.; Yu, H.; Chen, X., Coadministration of Vascular      Disrupting Agents and Nanomedicines to Eradicate Tumors from Peripheral andCentral Regions. Small 2015, 11, 3755-3761. (IF=10.856)

17. Li, M.; Tang, Z; Zhang, D.; Sun, H.; Liu, H.; Zhang, Y.; Zhang, Y.; Chen, X.,      Doxorubicin-loaded Polysaccharide Nanoparticles Suppress the Growth ofMurine Colorectal Carcinoma and Inhibit the Metastasis of Murine MammaryCarcinoma in Rodent Models. Biomaterials 2015, 51, 161-172. (IF=10.273)

18. Song, w.; Tang, Z; Zhang, D.; Zhang, Y.; Yu, H.; Li, M.; Lv, S.; Sun, H.; Deng, M.; Chen, X., Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin. Biomaterials 2014, 35, 3005-3014. (IF=10.273)