生态室副高级职员

姓  名

许维国

学 位

博士

职  务

 无

职 称

副研究员

研究组

生物高分子研究组

办公室

加工基地3012室

电  话

0431-85262077

E-mail

wgxu@ciac.ac.cn

2005.09-2010.07，吉林大学，公共卫生学院，预防医学、学士

2010.09-2013.06，吉林大学，公共卫生学院，劳动卫生与环境卫生学，硕士

2010.09-2013.06，中科院长春应用化学研究所，中科院生态环境高分子材料重点实验室，研究实习员

2019.09-至今，    中国科学技术大学，应用化学与工程学院，工程博士在读

2015.07-至今，    中科院长春应用化学研究所，中科院生态环境高分子材料重点实验室，助研、副研究员

肿瘤疫苗作为肿瘤免疫治疗不容忽视的分支，它是通过表达特异性的、具有免疫原性的肿瘤抗原，在细胞因子、趋化因子等佐剂的辅助下，增强或激活机体自身抗肿瘤免疫反应，而达到杀伤、清除肿瘤的目的。基于前期研究工作，本人拟采用不同手性的聚乳酸作为免疫佐剂和运载工具，制备肿瘤疫苗用于癌症的预防以及治疗。具体是以不同手性聚乳酸以及STING激动剂引发聚合的聚乳酸作为免疫佐剂开发两类肿瘤疫苗。其中STING激动剂作为癌症免疫治疗的辅剂，可在增强适应性免疫作用的同时可有效激活免疫记忆细胞。通过对肿瘤疫苗预防和治疗效果的评价，优化聚乳酸的分子量以及肿瘤疫苗粒径等特性，进而开发出具有临床应用潜力的聚乳酸肿瘤疫苗。

1. Wang, J.^*, Xu, W. G.^*, Zhang, N.^*, Yang, C. S., Xu, H. W., Wang, Z. T., Li, B. S.*, Ding, J. X.*, Chen, X. S., X-ray-responsive polypeptide nanogel for concurrent chemoradiotherapy. Journal of Controlled Release, 2021, 332, 1-9.

2.  Ma, Wen*, Chen, Qiling*, Xu, Weiguo*, Yu, Meng, Yang, Yuanyuan, Zou, Binhua, Zhang, Yu Shrike*, Ding, Jianxun*, Yu, Zhiqiang*, Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer. Nano Research, 2021, 14 (3), 846-857.

3. Jiang, Zhongyu, Feng, Xiangru, Zou, Haoyang, Xu, Weiguo*, Zhuang, Xiuli*, Poly (l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization. Bioactive Materials, 2021, 6 (9), 2688-2697.

4. Huang, Xu*, Xu, Weiguo*, Li, Mingqiang, Zhang, Ping, Zhang, Yu Shrike, Ding, Jianxun*, Chen, Xuesi, Antiviral biomaterials. Matter, 2021, 4 (6), 1892-1918.

5.  Gao, Quan, Duan, Lijie, Feng*, Xiangru, Xu, Weiguo*, Superiority of poly(l-lactic acid) microspheres as dermal fillers. Chinese Chemical Letters, 2021, 32 (1), 577-582.

6.  Yin, Fei^*, Wang, Zongyi*, Jiang, Yafei, Zhang, Tao, Wang, Zhuoying, Hua, Yingqi, Song, Zhiming*, Liu, Jianhua, Xu, Weiguo*, Xu, Jing*, Cai, Zhengdong*, Ding, Jianxun, Reduction-responsive polypeptide nanomedicines significantly inhibit progression of orthotopic osteosarcoma. Nanomedicine: Nanotechnology, Biology and Medicine, 2020, 23, 102085.

7.  Zhang, Yanbo*, Zhang, Jin*, Xu, Weiguo*, Xiao, Gao, Ding, Jianxun*, Chen, Xuesi, Tumor microenvironment-labile polymer-doxorubicin conjugate thermogel combined with docetaxel for in situ synergistic chemotherapy of hepatoma. Acta Biomaterialia, 2018, 77, 63-73.

8. Li, Jiannan*, Xu, Weiguo*, Li, Di*, Liu, Tongjun, Zhang, Yu Shrike*, Ding, Jianxun*, Chen, Xuesi, Locally deployable nanofiber patch for sequential drug delivery in treatment of primary and advanced orthotopic hepatomas. Acs Nano., 2018, 12 (7), 6685-6699.

9.  Shi, Bo*, Huang, Kexin*, Ding, Jianxun*, Xu, Weiguo*, Yang, Yu,Liu, Haiyan*, Yan, Lesan*, Chen, Xuesi*, Intracellularly swollen polypeptide nanogel assists hepatoma chemotherapy. Theranostics, 2017. 7(3):703-716

10. Xu, Weiguo, Ding, Jianxun*, Chen, Xuesi, Reduction-responsive polypeptide micelles for intracellular delivery of antineoplastic agent. Biomacromolecules, 2017, 18 (10), 3291-3301.